Davies L, McLeod J G, Muir A, Hensley W J
Department of Neurology, Royal Prince Alfred Hospital, NSW.
Clin Exp Neurol. 1987;24:5-10.
The levels of myelin basic protein (MBP) in the cerebrospinal fluid (CSF) have been evaluated as a method of detecting central nervous system (CNS) demyelination. MBP levels were measured in the CSF of 129 patients with neurological illnesses of whom 26 had a demyelinating illness. High levels of MBP were found in 81% of patients with recent episodes of demyelination but were not seen in patients with multiple sclerosis that was clinically stable or in remission. Patients with CNS trauma also had high levels of MBP in their CSF. The detection of a high level of MBP in CSF may be useful in the diagnosis of acute CNS demyelination but the finding is not specific for multiple sclerosis.
脑脊液（CSF）中髓鞘碱性蛋白（MBP）的水平已被评估为检测中枢神经系统（CNS）脱髓鞘的一种方法。对129例神经系统疾病患者的脑脊液进行了MBP水平检测，其中26例患有脱髓鞘疾病。81%近期有脱髓鞘发作的患者脑脊液中MBP水平较高，但临床稳定或缓解的多发性硬化症患者脑脊液中未检测到高水平的MBP。中枢神经系统创伤患者的脑脊液中MBP水平也较高。脑脊液中高水平MBP的检测可能有助于急性中枢神经系统脱髓鞘的诊断，但这一发现并非多发性硬化症所特有。
