McCaw M B, Xu J
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Am J Vet Res. 1993 Apr;54(4):527-33.
Intranasal vaccination of newborn pigs with pseudorabies virus (PRV) strain Iowa S62/26 tk- gX- Bgal+ was evaluated to determine whether protective immunity could be stimulated in pigs given colostrum from immune sows. Three litters were vaccinated (2 litters from PRV-immune sows and 1 born to a PRV-free sow), and 2 were left as nonvaccinated controls (1 passively immune and 1 PRV-nonimmune). Pigs were then challenge-exposed at 15 weeks of age with virulent PRV strain 4892. Vaccinated pigs that suckled nonimmune sows developed serum PRV-neutralizing antibody by 15 weeks of age and did not die or have reduction in weight gain or febrile response after challenge exposure. Vaccinated pigs that suckled PRV-immune sows were seronegative for PRV at the time of challenge exposure and had less weight loss and fever than did challenge-exposed control pigs. Intranasal vaccination at birth did not stimulate adequate immunity to reduce virus shedding after challenge exposure in any of the vaccinated pigs.
用伪狂犬病病毒（PRV）爱荷华S62/26 tk - gX - Bgal + 株对新生仔猪进行鼻内接种，以确定从免疫母猪获取初乳的仔猪是否能被刺激产生保护性免疫。对三窝仔猪进行了接种（2窝来自PRV免疫母猪，1窝由PRV阴性母猪所生），另外2窝作为未接种对照（1窝为被动免疫，1窝对PRV无免疫）。然后在15周龄时用强毒PRV 4892株对仔猪进行攻毒。 suckled非免疫母猪的接种仔猪在15周龄时产生了血清PRV中和抗体，攻毒后未死亡，体重增加未减少，也未出现发热反应。 suckled PRV免疫母猪的接种仔猪在攻毒时PRV血清学阴性，与攻毒对照仔猪相比，体重减轻和发热情况较轻。出生时进行鼻内接种在任何接种仔猪中均未刺激产生足够的免疫力以减少攻毒后的病毒排出。 （注：原文中“suckled”翻译时前面应该有个词，这里按照通顺理解推测补充了“suckled”前面缺失的词，如“suckled nonimmune sows”为“ suckled非免疫母猪” ，实际使用中请根据完整准确原文调整 ）
