Jackson M E, Campo M S, Gaukroger J M
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, U.K.
Crit Rev Oncog. 1993;4(3):277-91.
Papillomaviruses have been identified as causative agents of squamous cell carcinoma in humans and other mammals, and several papillomavirus-encoded proteins have been found to possess transforming activity. However, papillomavirus infection per se appears insufficient to elicit carcinomas in the majority of cases, and other agents have been implicated as cofactors. This review presents epidemiological studies linking environmental carcinogens to papillomavirus-associated carcinoma, and evidence from experimental systems that attempt to identify the targets of carcinogens and viral oncoproteins, and the interactions of both in progression to carcinoma.
乳头瘤病毒已被确认为人类和其他哺乳动物鳞状细胞癌的致病因子，并且已发现几种乳头瘤病毒编码的蛋白质具有转化活性。然而，在大多数情况下，乳头瘤病毒感染本身似乎不足以引发癌症，其他因素也被认为是辅助因子。这篇综述介绍了将环境致癌物与乳头瘤病毒相关癌症联系起来的流行病学研究，以及来自实验系统的证据，这些实验系统试图确定致癌物和病毒癌蛋白的靶点，以及两者在癌症进展过程中的相互作用。
