Poulin P, Pittman Q J
Department of Medical Physiology, University of Calgary, Alberta, Canada.
J Neuroendocrinol. 1993 Feb;5(1):33-9. doi: 10.1111/j.1365-2826.1993.tb00361.x.
The recent observation that the central oxytocin (OT) receptor has high affinity for both OT and arginine vasopressin (AVP) raises the possibility that it may be involved in some of the central actions of AVP. Repeated intracerebroventricular (icv) injections of AVP in rats evoke an unusual sensitization phenomenon in that a first exposure to the peptide enhances the sensitivity (sensitization) of the brain to a second exposure. This report investigates the possibility that the OT receptor may be involved in the mediation of the phenomenon of sensitization, using OT, a specific OT receptor agonist, [Thr4,Gly7]OT, and a specific OT receptor antagonist, d(CH2)5,[Tyr(Me)2,Thr4,Tyr-NH2(9)]OVT (compound 6; cpd 6), as well as a V1 AVP receptor antagonist, d(CH2)5Tyr(Me)AVP. Peptides were injected icv in conscious, adult male Sprague-Dawley rats.(ABSTRACT TRUNCATED AT 250 WORDS)
最近的观察发现，中枢催产素（OT）受体对OT和精氨酸加压素（AVP）都具有高亲和力，这增加了其可能参与AVP某些中枢作用的可能性。在大鼠中反复脑室内（icv）注射AVP会引发一种不寻常的致敏现象，即首次接触该肽会增强大脑对第二次接触的敏感性（致敏）。本报告使用OT、一种特异性OT受体激动剂[Thr4，Gly7]OT、一种特异性OT受体拮抗剂d(CH2)5，[Tyr(Me)2，Thr4，Tyr-NH2(9)]OVT（化合物6；cpd 6）以及一种V1 AVP受体拮抗剂d(CH2)5Tyr(Me)AVP，研究OT受体是否可能参与致敏现象的介导。将肽类注射到清醒的成年雄性Sprague-Dawley大鼠的脑室内。（摘要截短至250字）
