苏拉明：一种具有独特生物学效应的抗癌药物。 - Suppr

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超能文献

Suramin: an anticancer drug with unique biological effects.

作者信息

Larsen A K

机构信息

Department of Molecular Pharmacology, INSERM U 140, CNRS URA 147, Institut Gustave Roussy, Villejuif, France.

出版信息

Cancer Chemother Pharmacol. 1993;32(2):96-8. doi: 10.1007/BF00685609.

DOI:10.1007/BF00685609

PMID:8387401

Abstract

摘要

相似文献

Suramin: an anticancer drug with unique biological effects.苏拉明：一种具有独特生物学效应的抗癌药物。

Cancer Chemother Pharmacol. 1993;32(2):96-8. doi: 10.1007/BF00685609.

Stimulation of tumor growth in vitro and in vivo by suramin on the VX2 model.

Invest New Drugs. 1995;13(1):51-3. doi: 10.1007/BF02614220.

Suramin augments the antitumor and antimetastatic activity of pentoxifylline in B16F10 melanoma.苏拉明增强了己酮可可碱在B16F10黑色素瘤中的抗肿瘤和抗转移活性。

Int J Cancer. 2007 Oct 1;121(7):1600-8. doi: 10.1002/ijc.22843.

Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.

Biochem Biophys Res Commun. 1994 Sep 30;203(3):1574-80. doi: 10.1006/bbrc.1994.2366.

Effect of suramin on differentiation of human stomach cancer cell lines.苏拉明对人胃癌细胞系分化的影响。

J Korean Med Sci. 1997 Oct;12(5):433-42. doi: 10.3346/jkms.1997.12.5.433.

Suramin inhibits laminin- and thrombospondin-mediated melanoma cell adhesion and migration and binding of these adhesive proteins to sulfatide.

Cancer Res. 1990 Sep 15;50(18):5937-42.

Suramin, an anti-cancer drug, inhibits protein kinase C and induces differentiation in neuroblastoma cell clone NB2A.

FEBS Lett. 1989 Nov 20;258(1):156-8. doi: 10.1016/0014-5793(89)81639-4.

Opposing effects of suramin and DL-alpha-difluoromethylornithine on polyamine metabolism contribute to a synergistic action on B16 melanoma cell growth in vitro.苏拉明和DL-α-二氟甲基鸟氨酸对多胺代谢的相反作用有助于它们在体外对B16黑色素瘤细胞生长产生协同作用。

Anticancer Res. 1998 Mar-Apr;18(2A):863-70.

Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells.苏拉明抑制HepG2细胞的生长，但却促进其胰岛素样生长因子II的表达。

Cancer Res. 1993 Feb 1;53(3):652-7.

Estrogen receptor-positive human epithelial ovarian carcinoma cells respond to the antitumor drug suramin with increased proliferation: possible insight into ER and epidermal growth factor signaling interactions in ovarian cancer.雌激素受体阳性的人上皮性卵巢癌细胞对抗肿瘤药物苏拉明的反应是增殖增加：这可能为深入了解卵巢癌中雌激素受体和表皮生长因子信号相互作用提供线索。

Gynecol Oncol. 2004 Sep;94(3):705-12. doi: 10.1016/j.ygyno.2004.05.059.

引用本文的文献

Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin.NF-Y 转录因子抑制物苏拉明的结构基础。

Cells. 2020 Oct 29;9(11):2370. doi: 10.3390/cells9112370.

Direct High-Throughput Screening Assay for mRNA Cap Guanine-N7 Methyltransferase Activity.直接高通量筛选测定 mRNA 帽鸟嘌呤-N7 甲基转移酶活性。

Chemistry. 2020 Sep 1;26(49):11266-11275. doi: 10.1002/chem.202001036. Epub 2020 Aug 10.

A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers.旧药的新WNT靶点：针对WNT依赖型癌症的药物重新定位

Cancers (Basel). 2016 Jul 14;8(7):66. doi: 10.3390/cancers8070066.

Targeting VEGF and Its Receptors for the Treatment of Osteoarthritis and Associated Pain.靶向血管内皮生长因子及其受体治疗骨关节炎及相关疼痛

J Bone Miner Res. 2016 May;31(5):911-24. doi: 10.1002/jbmr.2828. Epub 2016 Apr 8.

Suramin inhibits cell proliferation in ovarian and cervical cancer by downregulating heparanase expression.苏拉明通过下调乙酰肝素酶的表达来抑制卵巢癌和宫颈癌中的细胞增殖。

Cancer Cell Int. 2015 May 13;15:52. doi: 10.1186/s12935-015-0196-y. eCollection 2015.

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer.细胞周期：癌症中调控、失调及治疗靶点的综述

Cell Prolif. 2003 Jun;36(3):131-49. doi: 10.1046/j.1365-2184.2003.00266.x.

Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.苏拉明治疗人胶质瘤异种移植瘤；对肿瘤血管和氧合状态的影响。

J Neurooncol. 1999 Sep;44(2):129-36. doi: 10.1023/a:1006363215260.

Angiogenesis: possibilities for therapeutic interventions.血管生成：治疗干预的可能性

Pharm World Sci. 1998 Dec;20(6):225-35. doi: 10.1023/a:1008600603059.

本文引用的文献

Effect of suramin on the activities of degradative enzymes of sphingolipids in rats.苏拉明对大鼠鞘脂降解酶活性的影响。

Res Commun Chem Pathol Pharmacol. 1981 Apr;32(1):87-97.

Experimental animal model for mucopolysaccharidosis: suramin-induced glycosaminoglycan and sphingolipid accumulation in the rat.黏多糖贮积症的实验动物模型：苏拉明诱导大鼠体内糖胺聚糖和鞘脂蓄积

Proc Natl Acad Sci U S A. 1980 Jun;77(6):3700-4. doi: 10.1073/pnas.77.6.3700.

Platelet-derived growth factor receptors form a high affinity state in membrane preparations. Kinetics and affinity cross-linking studies.血小板衍生生长因子受体在膜制剂中形成高亲和力状态。动力学和亲和交联研究。

J Biol Chem. 1984 Apr 25;259(8):5287-94.

Intralysosomal accumulation of polyanions. II. Polyanion internalization and its influence on lysosomal pH and membrane fluidity.多阴离子在溶酶体内的蓄积。II. 多阴离子的内化及其对溶酶体pH值和膜流动性的影响。

J Cell Biol. 1982 Jun;93(3):875-82. doi: 10.1083/jcb.93.3.875.

Intralysosomal accumulation of polyanions. I. Fusion of pinocytic and phagocytic vacuoles with secondary lysosomes.多阴离子在溶酶体内的积累。I. 胞饮泡和吞噬泡与次级溶酶体的融合。

J Cell Biol. 1982 Jun;93(3):866-74. doi: 10.1083/jcb.93.3.866.

Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III.苏拉明在体外对T细胞的保护作用，使其免受人类嗜T淋巴细胞病毒III型（HTLV-III）的感染性和细胞病变效应的影响。

Science. 1984 Oct 12;226(4671):172-4. doi: 10.1126/science.6091268.

The effects of antimicrobial agents on ribonucleic acid polymerase.抗菌剂对核糖核酸聚合酶的影响。

Mol Pharmacol. 1965 Jul;1(1):1-13.

Suramin: a potent ATPase inhibitor which acts on the inside surface of the sodium pump.苏拉明：一种作用于钠泵内表面的强效ATP酶抑制剂。

Biochim Biophys Acta. 1973 Aug 22;318(2):262-72. doi: 10.1016/0005-2736(73)90119-3.

Suramin: a potent inhibitor of the calcium transport in sarcoplasmic reticulum.

Biochem Biophys Res Commun. 1974 Jul 10;59(1):322-5. doi: 10.1016/s0006-291x(74)80209-3.

Suramin binds to platelet-derived growth factor and inhibits its biological activity.苏拉明与血小板衍生生长因子结合并抑制其生物活性。

J Cell Biochem. 1985;29(3):265-73. doi: 10.1002/jcb.240290310.

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