博来霉素对可渗透肉瘤细胞中复制性DNA合成的抑制及对非程序性DNA合成的诱导作用
Inhibition of replicative DNA synthesis and induction of unscheduled DNA synthesis in permeable sarcoma cell by bleomycin.
作者信息
Seki S, Oda T
出版信息
Biochim Biophys Acta. 1978 Dec 21;521(2):520-8. doi: 10.1016/0005-2787(78)90294-0.
Unscheduled DNA synthesis was induced by bleomycin in isolated rat liver nuclei and in permeable mouse ascites sarcoma cells. ATP significantly enhanced the bleomycin effect of inducing unscheduled DNA synthesis. Replicative DNA synthesis in permeable mouse ascites sarcoma cells was inhibited by bleomycin. The apparent inhibition or stimulation by bleomycin of in vitro DNA synthesis was thought to be determined by a balance between inhibited DNA replicase activity and induced unscheduled DNA synthesis.
博来霉素可在分离的大鼠肝细胞核及可渗透的小鼠腹水肉瘤细胞中诱导非程序性 DNA 合成。ATP 显著增强了博来霉素诱导非程序性 DNA 合成的作用。博来霉素可抑制可渗透的小鼠腹水肉瘤细胞中的复制性 DNA 合成。博来霉素对体外 DNA 合成的明显抑制或刺激作用被认为是由被抑制的 DNA 复制酶活性与诱导的非程序性 DNA 合成之间的平衡所决定的。
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