通透的小鼠肉瘤细胞中复制性DNA合成和博来霉素诱导的非预定DNA合成对溴化乙锭的敏感性差异
Differential sensitivity to ethidium bromide of replicative DNA synthesis and bleomycin-induced unscheduled DNA synthesis in permeable mouse sarcoma cells.
作者信息
Seki S, Oda T
出版信息
Experientia. 1984 Aug 15;40(8):869-71. doi: 10.1007/BF01952001.
PMID:6205893
Abstract
Replicative DNA synthesis in permeable mouse sarcoma cells was more sensitive to ethidium bromide (EtBr) than bleomycin-induced unscheduled DNA synthesis (UDS). A similar difference in sensitivity to EtBr was observed between DNA polymerases alpha and beta. The difference in sensitivity to EtBr of replicative DNA synthesis and UDS in the present system seems to reflect mainly the sensitivity difference between DNA polymerases alpha and beta.
摘要
在可渗透的小鼠肉瘤细胞中，复制性DNA合成对溴化乙锭（EtBr）的敏感性高于博来霉素诱导的非预定DNA合成（UDS）。在DNA聚合酶α和β之间也观察到对EtBr敏感性的类似差异。本系统中复制性DNA合成和UDS对EtBr敏感性的差异似乎主要反映了DNA聚合酶α和β之间的敏感性差异。
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