Kashuba V I, Kavsan V M, Ryndich A V, Lazurkevich Z V, Zubak S V, Popov S V, Dostalova V, Glozhanek I
Mol Biol (Mosk). 1993 Mar-Apr;27(2):436-50.
Subgroup C avian sarcoma viruses efficiently infect and transform but poorly replicate in duck cells. Nucleotide sequence analysis of Prague strain of Rous sarcoma virus adapted by numerous passages on duck embryonic fibroblasts (daPr-RSV-C) showed that adaptation of originally chicken virus to duck cells correlated with changes in viral genome, first of all in gp85-coding domain of env-gene. Besides, changes in LTR and src-gene sequences could play a role in widening of host range for this virus. The major changes of daPr-RSV-C in comparison with original Pr-RSV-C appeared to be the result of homologous recombinations with corresponding regions of chicken endogenous retroviruses.
C亚群禽肉瘤病毒能有效感染并转化鸭细胞，但在鸭细胞中的复制能力较差。对在鸭胚成纤维细胞上多次传代适应的劳氏肉瘤病毒布拉格株（daPr-RSV-C）进行核苷酸序列分析表明，最初的鸡病毒适应鸭细胞与病毒基因组的变化相关，首先是env基因的gp85编码域发生变化。此外，长末端重复序列（LTR）和src基因序列的变化可能在该病毒宿主范围的扩大中起作用。与原始的Pr-RSV-C相比，daPr-RSV-C的主要变化似乎是与鸡内源性逆转录病毒相应区域同源重组的结果。
