van der Kolk J H, van Hoorn C J, van Garderen E, van den Belt A J
Vakgroep Inwendige Ziekten en Voeding der Grote Huisdieren, Faculteit Diergeneeskunde, Utrecht.
Tijdschr Diergeneeskd. 1993 May 1;118(9):298-300.
An eighteen-year-old pony gelding was referred to the Faculty of Veterinary Medicine because of colic, due to cecal tympany. His haircoat was dull with long wavy hair. After medical treatment of the colic it was sent home three days later. Just before it had been dismissed the morning plasma glucose concentration measured 10.2 mmol.l-1. The basal plasma cortisol concentration was high (180 nmol.l1) and basal plasma ACTH concentration was highly elevated (> 960 pg.ml1). An ACTH-stimulation test was performed by intravenous administering of 0.25 mg synthetic ACTH 1 24 at 9.00 hours showing adrenocortical hyperfunction by an increase of plasma cortisol to 771 nmol.l-1. After 365 days the gelding was readmitted because of anorexia since two days, due to a mandibula fracture without obvious signs of osteoporosis. This time the morning plasma glucose concentration measured 11.9 mmol.l-1. Euthanasia was carried out and at necropsy both a mandibula fracture and a pituitary pars intermedia adenoma were found.
一匹18岁的去势小马因盲肠鼓气引起的绞痛被转诊至兽医学院。它的被毛暗淡且长而卷曲。绞痛经药物治疗后，三天后被送回家。就在出院前，早晨测得血浆葡萄糖浓度为10.2 mmol.l-1。基础血浆皮质醇浓度很高（180 nmol.l1），基础血浆促肾上腺皮质激素（ACTH）浓度大幅升高（> 960 pg.ml1）。上午9点通过静脉注射0.25 mg合成ACTH 1 24进行了ACTH刺激试验，结果显示肾上腺皮质功能亢进，血浆皮质醇增加至771 nmol.l-1。365天后，这匹去势小马因下颌骨骨折且无明显骨质疏松迹象导致的两天厌食再次入院。此次早晨测得血浆葡萄糖浓度为11.9 mmol.l-1。实施了安乐死，尸检时发现了下颌骨骨折和垂体中间部腺瘤。
