Drago F, Mauceri F, Nardo L, Valerio C, Genazzani A A, Grassi M
Institute of Pharmacology, University of Catania Medical School, Italy.
Brain Res Bull. 1993;31(5):485-9. doi: 10.1016/0361-9230(93)90113-p.
The phosphatidylcholine precursor, cytidine-diphosphocholine (CDP-choline), was injected intraperitoneally (IP) at the dose of 10 or 20 mg/kg/day for 20 days to 24-month-old male rats of the Sprague-Dawley strain that showed cognitive and motor deficits. The drug was also injected in animals with behavioral alterations induced pharmacologically with a single injection of the cholinergic receptor antagonist, scopolamine, with prenatal exposure to methylazoxymethanol (MAM rats), or with bilateral injections of kainic acid into the nucleus basalis magnocellularis (NBM). Learning and memory capacity of the animals, studied with tests of active and passive avoidance behavior, was improved after treatment with CDP-choline in all experimental groups. An improvement in motor performance and coordination in the rotorod and open field tests was also observed in aged rats. These results indicate that this drug affects central mechanisms involved in cognitive behaviors, probably through a cholinergic action.
将磷脂酰胆碱前体胞苷二磷酸胆碱（CDP-胆碱）以10或20毫克/千克/天的剂量腹腔注射（IP）给20只24月龄表现出认知和运动缺陷的Sprague-Dawley品系雄性大鼠，持续20天。该药物也被注射到通过单次注射胆碱能受体拮抗剂东莨菪碱、产前暴露于甲基氧化偶氮甲醇（MAM大鼠）或向大细胞基底核双侧注射海藻酸诱导行为改变的动物体内。在所有实验组中，用主动和被动回避行为测试研究动物的学习和记忆能力，经CDP-胆碱治疗后得到改善。在老年大鼠的转棒试验和旷场试验中也观察到运动性能和协调性的改善。这些结果表明，该药物可能通过胆碱能作用影响参与认知行为的中枢机制。
