Drago F, Mauceri F, Nardo L, Valerio C, Lauria N, Rampello L, Guidi G
Institute of Pharmacology, University of Catania Medical School, Italy.
Pharmacol Biochem Behav. 1992 Feb;41(2):445-8. doi: 10.1016/0091-3057(92)90124-x.
The phosphorylcholine precursor, L-alpha-glycerylphosphorylcholine (alpha-GPC), was injected at the dose of 100 mg/kg/day for 20 days to aged male rats of the Sprague-Dawley strain, 24 months old, showing a deficit of learning and memory capacity. The drug was also administered to rats with amnesia induced pharmacologically with bilateral injections of kainic acid into the nucleus basalis magnocellularis (NBM). Learning and memory capacity of the animals, studied with tests of active and passive avoidance behavior, was improved after treatment with alpha-GPC in all experimental groups. These results indicate that this drug affects cognitive mechanisms in the rat through an involvement of central neurotransmission.
将磷酰胆碱前体L-α-甘油磷酰胆碱（α-GPC）以100毫克/千克/天的剂量注射给24月龄、表现出学习和记忆能力缺陷的Sprague-Dawley品系老年雄性大鼠，持续20天。该药物也被给予通过向大细胞基底核（NBM）双侧注射海藻酸诱导产生失忆的大鼠。在所有实验组中，用α-GPC治疗后，通过主动和被动回避行为测试研究的动物学习和记忆能力均得到改善。这些结果表明，该药物通过参与中枢神经传递来影响大鼠的认知机制。
