Or K, Richards A M, Espiner E A, Yandle T, Gilchrist N, Sainsbury R
Department of Endocrinology, Princess Margaret Hospital, Christchurch, New Zealand.
J Clin Endocrinol Metab. 1993 May;76(5):1271-4. doi: 10.1210/jcem.76.5.8388403.
Low dose infusions of atrial natriuretic peptide (ANP) have significant biological effects in young adults. In view of the accumulating evidence of age-related changes in ANP physiology, we investigated the effects of a 2-h low dose infusion of ile12-ANP (1.5 pmol/kg/min) in eight healthy, supine, normotensive elderly men in a single blind, random order, placebo-controlled study. Calculated MCR of ANP was 3.3 +/- 0.4 L/min, disappearance half-life 4.1 +/- 0.4 min, and volume of distribution 21 +/- 4 L. The ile-ANP infusions induced the expected significant (3-fold) increases in plasma ANP immunoreactivity in association with enhancement of both plasma and urine cyclic guanosine monophosphate. Despite this, there were no measurable natriuretic effects or changes in blood pressure, and the activities of the renin-angiotensin-aldosterone and sympathetic nervous systems were unchanged. These findings suggest an abnormality in the post-cyclic guanosine monophosphate effector of ANP among elderly normotensive men.
低剂量输注心房利钠肽（ANP）对年轻人具有显著的生物学效应。鉴于有关ANP生理学随年龄变化的证据不断积累，我们在一项单盲、随机顺序、安慰剂对照研究中，对8名健康、仰卧、血压正常的老年男性进行了2小时低剂量输注ile12-ANP（1.5 pmol/kg/分钟）的研究。计算得出ANP的MCR为3.3±0.4升/分钟，消除半衰期为4.1±0.4分钟，分布容积为21±4升。ile-ANP输注导致血浆ANP免疫反应性显著升高（3倍），同时血浆和尿液中环鸟苷酸均增强。尽管如此，未观察到利钠效应或血压变化，肾素-血管紧张素-醛固酮系统和交感神经系统的活性也未改变。这些发现提示血压正常的老年男性中ANP的环鸟苷酸后效应器存在异常。
