单个RNA病毒颗粒的数万亿倍扩增无法克服穆勒棘轮效应。
Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.
作者信息
Duarte E A, Clarke D K, Moya A, Elena S F, Domingo E, Holland J
机构信息
Department of Biology, University of California, San Diego, La Jolla 92093-0116.
出版信息
J Virol. 1993 Jun;67(6):3620-3. doi: 10.1128/JVI.67.6.3620-3623.1993.
Abstract
We showed earlier that transfers of large populations of RNA viruses lead to fitness gains and that repeated genetic bottleneck transfers result in fitness losses due to Muller's ratchet. In the present study, we examined the effects of genetic bottleneck passages intervening between population passages, a process akin to some natural viral transmissions, using vesicular stomatitis virus as a model. Our findings show that the pronounced fitness increases that occur during two successive population passages cannot overcome the fitness decreases caused by a single intervening genetic bottleneck passage. The implications for natural transmissions of RNA viruses are discussed.
摘要
我们之前表明，大量RNA病毒的转移会导致适应性增加，而由于穆勒棘轮效应，反复的遗传瓶颈转移会导致适应性损失。在本研究中，我们以水疱性口炎病毒为模型，研究了介于群体传代之间的遗传瓶颈传代的影响，这一过程类似于一些自然病毒传播。我们的研究结果表明，在连续两次群体传代过程中出现的显著适应性增加无法克服由单个中间遗传瓶颈传代所导致的适应性降低。本文讨论了这一结果对RNA病毒自然传播的影响。
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本文引用的文献
1
THE RELATION OF RECOMBINATION TO MUTATIONAL ADVANCE.
Mutat Res. 1964 May;106:2-9. doi: 10.1016/0027-5107(64)90047-8.
2
SURVIVAL OF MEASLES VIRUS IN AIR.
Nature. 1964 Mar 7;201:1054-5. doi: 10.1038/2011054a0.
3
Studies on an attenuated measles-virus vaccine. I. Development and preparations of the vaccine: technics for assay of effects of vaccination.
N Engl J Med. 1960 Jul 28;263:153-9. doi: 10.1056/NEJM196007282630401.
4
Genetic bottlenecks and population passages cause profound fitness differences in RNA viruses.
J Virol. 1993 Jan;67(1):222-8. doi: 10.1128/JVI.67.1.222-228.1993.
5
Selective neutrality of 6PGD allozymes in E. coli and the effects of genetic background.
Genetics. 1980 Dec;96(4):801-17. doi: 10.1093/genetics/96.4.801.
6
Antigenic determinants of vesicular stomatitis virus: analysis with antigenic variants.
J Immunol. 1983 Jan;130(1):394-8.
7
The interaction of antibody with the major surface glycoprotein of vesicular stomatitis virus. II. Monoclonal antibodies of nonneutralizing and cross-reactive epitopes of Indiana and New Jersey serotypes.
Virology. 1982 Aug;121(1):168-74. doi: 10.1016/0042-6822(82)90126-x.
8
9
Effect of route of inoculation on experimental respiratory viral disease in volunteers and evidence for airborne transmission.
Bacteriol Rev. 1966 Sep;30(3):517-29. doi: 10.1128/br.30.3.517-529.1966.
10
Assessment of experimental and natural viral aerosols.
Bacteriol Rev. 1966 Sep;30(3):576-88. doi: 10.1128/br.30.3.576-588.1966.
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