Miller W R, Hulme M J, Cho-Chung Y S, Elton R A
ICRF, Medical Oncology Unit, Western General Hospital, Edinburgh, U.K.
Eur J Cancer. 1993;29A(7):989-91. doi: 10.1016/s0959-8049(05)80207-2.
Total level and type of cyclic AMP binding proteins have been measured in 117 breast cancers. Six major molecular species of binding proteins were detected. The pattern and relative proportion of binding proteins varied between individual tumours. However, there were highly significant correlations between the expression of different binding proteins, including positive relationships between 52 and 67 kD proteins, 43 kD and both 39 and 37 kD proteins and inverse correlations between 48 and 52 kD, 37 and 67 kD proteins. The expression of three binding proteins (48, 43 and 39 kD) was also positively related to total binding whereas that of the remaining three bindings proteins (67, 52 and 37 kD) was negatively correlated with total levels. It may be that differential expression of certain types of binding protein are the underlying rationale for our previously published finding that tumours with high levels of high binding protein are associated with poor prognosis.
已对117例乳腺癌中的环磷酸腺苷结合蛋白的总量和类型进行了测定。检测到六种主要的结合蛋白分子种类。结合蛋白的模式和相对比例在各个肿瘤之间有所不同。然而，不同结合蛋白的表达之间存在高度显著的相关性，包括52kD和67kD蛋白之间、43kD与39kD和37kD蛋白之间呈正相关，以及48kD与52kD、37kD与67kD蛋白之间呈负相关。三种结合蛋白（48kD、43kD和39kD）的表达也与总结合呈正相关，而其余三种结合蛋白（67kD、52kD和37kD）的表达与总量呈负相关。可能某些类型结合蛋白的差异表达是我们之前发表的研究结果的潜在理论基础，即具有高水平高结合蛋白的肿瘤与预后不良相关。
