有证据表明内源性精氨酸加压素（AVP）参与维持大鼠肾上腺球状带的生长和类固醇生成能力。

Evidence that endogenous arginine-vasopressin (AVP) is involved in the maintenance of the growth and steroidogenic capacity of rat adrenal zona glomerulosa.

作者信息

Mazzocchi G, Markowska A, Malendowicz L K, Musajo F, Meneghelli V, Nussdorfer G G

机构信息

Department of Anatomy, University of Padua, Italy.

出版信息

J Steroid Biochem Mol Biol. 1993 Apr;45(4):251-6. doi: 10.1016/0960-0760(93)90339-x.

DOI:10.1016/0960-0760(93)90339-x

PMID:8388707

Abstract

A 7-day subcutaneous infusion with the AVP antagonist [Deamino-Pen1, Val4, D-Arg8]-vasopressin (AVP-A; 3 nmol.kg-1 x min-1) significantly lowered plasma aldosterone concentration in rats, without affecting the plasma levels of ACTH and corticosterone. Prolonged AVP-A treatment caused a marked atrophy of adrenal zona glomerulosa (ZG) and its parenchymal cells, without inducing any significant change in zona fasciculata morphology. Isolated ZG cells from AVP-A-infused rats evidenced a notable decrease in both their basal and maximally-stimulated aldosterone production. The simultaneous infusion of rats with AVP (3 nmol.kg-1 x min-1) completely reversed all these effects of AVP-A. These findings suggest that endogenous AVP may be specifically involved in the maintenance of the growth and steroidogenic capacity of rat adrenal ZG. Moreover, they seem to indicate that under basal conditions the pituitary-adrenal-glucocorticoid axis is independent of AVP release.

摘要

用抗利尿激素拮抗剂[脱氨基- Pen1，Val4，D-精氨酸8]-血管加压素（AVP-A；3 nmol·kg-1·min-1）进行7天的皮下输注，可显著降低大鼠血浆醛固酮浓度，而不影响促肾上腺皮质激素和皮质酮的血浆水平。长期AVP-A治疗导致肾上腺球状带（ZG）及其实质细胞明显萎缩，而束状带形态未发生任何显著变化。从接受AVP-A输注的大鼠分离出的ZG细胞显示，其基础和最大刺激醛固酮分泌均显著减少。同时给大鼠输注AVP（3 nmol·kg-1·min-1）可完全逆转AVP-A的所有这些作用。这些发现表明，内源性AVP可能特异性参与维持大鼠肾上腺ZG的生长和类固醇生成能力。此外，它们似乎表明在基础条件下，垂体-肾上腺-糖皮质激素轴独立于AVP释放。