Yamada G, Takahashi M, Endo H, Doi T, Miyamoto R, Shimomura H, Yamamoto K, Tsuji T
First Department of Internal Medicine, Okayama University Medical School, Japan.
Gut. 1993;34(2 Suppl):S133-4. doi: 10.1136/gut.34.2_suppl.s133.
Seventy patients with hepatitis C virus (HCV) infection received alpha interferon at doses ranging from 3 to 10 million units (MU) daily for eight weeks, three times weekly for 12-24 weeks, or daily and three times weekly for 12-24 weeks. The efficacy of interferon was closely related to the initial blood HCV-RNA values in that these were lower in those who responded completely and partially compared with non-responders. Continuous reductions in HCV-RNA and improvements in the histology activity index score were seen in those who responded completely. In contrast, most of the partial and non-responders remained HCV-RNA positive.
70例丙型肝炎病毒（HCV）感染者接受了α干扰素治疗，剂量为每日300万至1000万单位（MU），持续8周，或每周3次，持续12 - 24周，或每日及每周3次，持续12 - 24周。干扰素的疗效与初始血液HCV - RNA值密切相关，完全和部分应答者的该值低于无应答者。完全应答者的HCV - RNA持续降低，组织学活动指数评分有所改善。相比之下，大多数部分应答者和无应答者的HCV - RNA仍为阳性。
