Zhang J M, Lin P F, Chen L L, Tang L H, Hong X Q, Liang B X, Chen H S, Teng L
Institute of Molecular Medicine, Zhejiang TCM College, Hangzhou.
Zhongguo Zhong Yao Za Zhi. 1993 Jan;18(1):49-52, 64.
The new guttae ophthalmic Xiaoxingzhang (XXZ) was extracted from Radix Actinidiae, a traditional Chinese herbal drug. The 50% inhibition concentration (IC50) of XXZ on type I Herpes Simplex Virus (HSV-1) in virus cell cultures is 165.48-174.73 micrograms/ml. However, XXZ concentrations greater than 400 micrograms/ml did not cause any microscopically visible disruption of vero cells. The efficacy of XXZ in the treatment of experimental Herpes Simplex Keratitis (HSK) in rabbits is higher than that of idoxuridine. The effective doses of XXZ are not toxic to corneal epithelium. The results suggest that XXZ as a new anti-HSV preparation is potentialy useful in the treatment of patients with HSK.
新型眼用滴眼剂小星章（XXZ）是从传统中草药猕猴桃根中提取的。XXZ在病毒细胞培养物中对I型单纯疱疹病毒（HSV-1）的50%抑制浓度（IC50）为165.48 - 174.73微克/毫升。然而，浓度大于400微克/毫升的XXZ并未引起任何在显微镜下可见的 vero 细胞破坏。XXZ治疗兔实验性单纯疱疹性角膜炎（HSK）的疗效高于碘苷。XXZ的有效剂量对角膜上皮无毒。结果表明，XXZ作为一种新型抗HSV制剂在治疗HSK患者方面具有潜在用途。
