Hubbard M J, Cohen P
Department of Biochemistry, University of Otago, New Zealand.
Trends Biochem Sci. 1993 May;18(5):172-7. doi: 10.1016/0968-0004(93)90109-z.
There is overwhelming evidence that the reversible phosphorylation of proteins regulates most aspects of cell life. However, the broad specificities displayed by many protein phosphatases and kinases in vitro dictates that their activities be strictly regulated in vivo. Recent evidence indicates that a novel class of proteins, known as targetting subunits, specifies the location, catalytic and regulatory properties of protein phosphatases and kinases, and thereby plays a key role in ensuring the fidelity of protein phosphorylation.
有压倒性的证据表明，蛋白质的可逆磷酸化调节着细胞生命的大部分方面。然而，许多蛋白质磷酸酶和激酶在体外表现出的广泛特异性表明，它们的活性在体内必须受到严格调节。最近的证据表明，一类新的蛋白质，即靶向亚基，决定了蛋白质磷酸酶和激酶的位置、催化和调节特性，从而在确保蛋白质磷酸化的保真度方面发挥关键作用。
