Brown A S, Mallinger A G, Renbaum L C
Department of Psychiatry, University of Pittsburgh School of Medicine, Pa.
Am J Psychiatry. 1993 Aug;150(8):1252-4. doi: 10.1176/ajp.150.8.1252.
Membrane phospholipids were measured in platelets of seven medication-free patients in the manic phase of bipolar affective disorder and seven healthy comparison subjects. The relative percentage of platelet membrane phosphatidylinositol-4,5-bisphosphate was significantly higher in the manic patients than in the comparison subjects. These results are consistent with an enhanced neuronal second messenger response after 5-hydroxytryptamine receptor stimulation followed by neurotransmitter release.
对7名处于双相情感障碍躁狂期且未服用药物的患者以及7名健康对照者的血小板进行了膜磷脂测定。躁狂患者血小板膜磷脂酰肌醇-4,5-二磷酸的相对百分比显著高于对照者。这些结果与5-羟色胺受体刺激后神经递质释放增强神经元第二信使反应一致。
