Dubovsky S L, Murphy J, Thomas M, Rademacher J
Department of Psychiatry, University of Colorado, School of Medicine, Denver.
Am J Psychiatry. 1992 Jan;149(1):118-20. doi: 10.1176/ajp.149.1.118.
The authors measured intracellular Ca2+ concentrations in four manic and five bipolar depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ concentrations were comparable. The patients' mean intracellular Ca2+ concentrations were higher than those of the comparison subjects and demonstrated more interindividual variation. These findings suggest a diffuse abnormality in mechanisms affecting intracellular calcium homeostasis in bipolar disorder.
作者测量了4名躁狂症患者、5名双相抑郁症患者以及7名对照受试者的细胞内钙离子浓度。血小板和淋巴细胞的细胞内钙离子浓度相当。患者的平均细胞内钙离子浓度高于对照受试者，且个体间差异更大。这些发现提示双相情感障碍患者在影响细胞内钙稳态的机制方面存在广泛异常。
