使用复数对配体-受体亲和力的一种透视。
A perspective into ligand-receptor affinities using complex numbers.
作者信息
Klotz I M
机构信息
Department of Chemistry, Northwestern University, Evanston, IL 60208-3113.
出版信息
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7191-4. doi: 10.1073/pnas.90.15.7191.
Abstract
The binding of ligands by a receptor can be expressed in an equation derived by a thermodynamic stoichiometric approach in which the stoichiometric equilibrium constants are all positive and real. An alternative binding equation can be derived algebraically in which the equilibrium constants can have values that are complex numbers. Some consequences of this situation are explored, and numerical values of the ghost equilibrium constants are evaluated for a number of ligand-receptor complexes.
摘要
受体与配体的结合可以用通过热力学化学计量方法推导的一个方程来表示，其中化学计量平衡常数均为正实数。也可以通过代数方法推导另一个结合方程，其中平衡常数可以取复数的值。本文探讨了这种情况的一些后果，并评估了许多配体 - 受体复合物的虚平衡常数的数值。
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