Takruri H, Ecanow B, Balagot R
J Pharm Sci. 1977 Feb;66(2):283-4. doi: 10.1002/jps.2600660241.
Coacervates have been suggested as models for cytoplasm since cytoplasm is also essentially an aqueous phase of water-protein-colloid complexes. This study on partition coefficient properties made use of coacervate phases as the nonpolar phases in equilibrium with polar water phases. The partition coefficients of four barbiturates were obtained, and their values correlated with those reported in the literature for systems using organic solvents as the nonpolar medium. These values also correlated with reported values for the absorption ranking of the barbiturates in the rat colon. The partition coefficients of theobromine and theophylline in gelatin-benzalkonium chloride coacervate systems were also found to correlate with the partition values reported in the literature for heptane-water and chloroform-water systems. Is is suggested that coacervate systems form a more realistic model for studying and predicting the absorption characteristics of drugs than do conventional organic solvent-water systems.
由于细胞质本质上也是水 - 蛋白质 - 胶体复合物的水相，因此有人提出凝聚层可作为细胞质的模型。这项关于分配系数特性的研究利用凝聚层相作为与极性水相平衡的非极性相。获得了四种巴比妥酸盐的分配系数，其值与文献中报道的使用有机溶剂作为非极性介质的系统的值相关。这些值也与巴比妥酸盐在大鼠结肠中的吸收排名的报道值相关。还发现可可碱和茶碱在明胶 - 苯扎氯铵凝聚层系统中的分配系数与文献中报道的庚烷 - 水和氯仿 - 水系统的分配值相关。有人认为，与传统的有机溶剂 - 水系统相比，凝聚层系统为研究和预测药物的吸收特性提供了一个更现实的模型。
