van Rensburg E J, van Heerden W F, Raubenheimer E J
Department of Medical Virology, University of Pretoria, South Africa.
In Vivo. 1993 May-Jun;7(3):229-32.
Human papillomavirus (HPV) infection is implicated in squamous cell carcinogenesis. Oesophageal carcinoma has a high incidence in certain geographical regions and, using different methods of detection, HPVs have been found in these tumours. HPV 6 and 11 are frequently detected in laryngeal papillomas, benign lesions which rarely become malignant. HPVs have been detected in squamous carcinoma of the larynx but more frequently, especially HPV 16, in verrucous carcinomas a distinct variant of squamous carcinoma. An increased density of Langerhans cells, important in immunosurveillance in squamous epithelium, has been associated with a more favourable patient prognosis in laryngeal and other carcinomas.
人乳头瘤病毒（HPV）感染与鳞状细胞癌的发生有关。食管癌在某些地理区域发病率较高，通过不同的检测方法，已在这些肿瘤中发现了HPV。HPV 6和11在喉乳头状瘤中经常被检测到，喉乳头状瘤是一种很少恶变的良性病变。HPV已在喉鳞状细胞癌中被检测到，但在疣状癌（鳞状细胞癌的一种独特变体）中更常见，尤其是HPV 16。朗格汉斯细胞密度增加在鳞状上皮的免疫监视中起重要作用，与喉癌和其他癌症患者更有利的预后相关。
