van Rensburg E J, Venter E H, Simson I W
Department of Medical Virology, University of Pretoria.
S Afr Med J. 1993 Jul;83(7):516-8.
A series of 10 oesophageal and 10 laryngeal squamous carcinomas was examined by means of immunocytochemistry and in situ DNA hybridisation to demonstrate human papillomavirus (HPV) infection. Changes in the epithelium adjacent to the carcinoma were found in 5 of 10 oesophageal and 7 of 10 laryngeal carcinomas. Viral antigens could not be detected with immunocytochemistry in any of the specimens. HPV 6, 11 and 16 were detected in 3 oesophageal specimens. In one of these, HPV 16 was detected in normal as well as malignant cells. HPV 7 was detected for the first time in a laryngeal carcinoma. Our results confirm previous reports of possible HPV involvement in the pathogenesis of aerodigestive carcinomas.
采用免疫细胞化学和原位DNA杂交技术对10例食管鳞状细胞癌和10例喉鳞状细胞癌进行检测，以证实人乳头瘤病毒（HPV）感染情况。在10例食管癌中有5例、10例喉癌中有7例发现癌旁上皮有改变。所有标本经免疫细胞化学检测均未发现病毒抗原。在3例食管标本中检测到HPV 6、11和16型。其中1例标本在正常细胞和恶性细胞中均检测到HPV 16型。在1例喉癌中首次检测到HPV 7型。我们的结果证实了先前有关HPV可能参与气消化道癌发病机制的报道。
