司帕沙星（CI-978；AT-4140）、氧氟沙星和环丙沙星的抗葡萄球菌活性。
Antistaphylococcal activities of sparfloxacin (CI-978; AT-4140), ofloxacin, and ciprofloxacin.
作者信息
Chaudhry A Z, Knapp C C, Sierra-Madero J, Washington J A
机构信息
Cleveland Clinic Foundation, Ohio 44195-5140.
出版信息
Antimicrob Agents Chemother. 1990 Sep;34(9):1843-5. doi: 10.1128/AAC.34.9.1843.
The activity of sparfloxacin (CI-978; AT-4140) was compared with those of ofloxacin and ciprofloxacin against clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis. All 10 ciprofloxacin-resistant staphylococci had reduced susceptibility to sparfloxacin and ofloxacin. Against 105 ciprofloxacin-susceptible strains of S. aureus, the sparfloxacin MIC for 90% of strains tested was at least fourfold lower than those of ciprofloxacin and ofloxacin, while against 104 ciprofloxacin-susceptible strains of S. epidermidis, the MIC of sparfloxacin for 90% of strains tested was twofold lower than that of ciprofloxacin and fourfold lower than that of ofloxacin. MBCs of sparfloxacin were less than or equal to 4 x MICs. The effects of inoculum size and pH variations, as well as the presence of serum, on the MICs of sparfloxacin were minimal. Subinhibitory concentrations of sparfloxacin did reduce adherence of S. epidermidis.
将司帕沙星（CI-978；AT-4140）与氧氟沙星和环丙沙星对金黄色葡萄球菌和表皮葡萄球菌临床分离株的活性进行了比较。所有10株对环丙沙星耐药的葡萄球菌对司帕沙星和氧氟沙星的敏感性均降低。对于105株对环丙沙星敏感的金黄色葡萄球菌菌株，90%受试菌株的司帕沙星MIC至少比环丙沙星和氧氟沙星低四倍，而对于104株对环丙沙星敏感的表皮葡萄球菌菌株，90%受试菌株的司帕沙星MIC比环丙沙星低两倍，比氧氟沙星低四倍。司帕沙星的MBC小于或等于4倍MIC。接种量、pH变化以及血清的存在对司帕沙星MIC的影响极小。亚抑菌浓度的司帕沙星确实降低了表皮葡萄球菌的黏附。
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