Rarey K E, Davis L E
Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville 32610.
Laryngoscope. 1993 Aug;103(8):904-9. doi: 10.1288/00005537-199308000-00012.
Temporal bones were examined from a 14-year-old male who died of sequelae of congenital cytomegalic inclusion disease (CID). Cytomegalovirus (CMV) was not isolated from inner ear fluid or multiple systemic tissues at the time of death. Examination of temporal bones revealed chronic pathology of both cochlear and vestibular sensory and nonsensory tissues. Endolymphatic hydrops was observed in the basal turn of the cochlear duct, while Reissner's membrane was collapsed in the more apical turns. Strial atrophy and a loss of cochlear hair cells were observed along the entire length of the basilar membrane. Vestibular neuroepithelial regions were degenerated and fibrosis was seen within the vestibular perilymphatic tissue spaces, suggesting prior labyrinthitis within the perilymph compartment in addition to the more typical pattern of endolabyrinthitis associated with human CMV infection. Distention of the saccular membrane was evident. In both cochlear and vestibular tissues, there were isolated regions of calcifications that appeared characteristic to that reported in other organ systems of individuals with CID. Collectively, these chronic, pathological findings in this case of CID demonstrate more extensive injury than has been identified in the previously reported acute temporal bone pathology of CID.
对一名死于先天性巨细胞包涵体病（CID）后遗症的14岁男性的颞骨进行了检查。死亡时，未从内耳液或多个全身组织中分离出巨细胞病毒（CMV）。颞骨检查显示耳蜗和前庭感觉及非感觉组织均存在慢性病变。在耳蜗管的底部转弯处观察到内淋巴积水，而在更顶部的转弯处，Reissner膜塌陷。在基底膜全长观察到血管纹萎缩和耳蜗毛细胞丢失。前庭神经上皮区域退化，在前庭外淋巴组织间隙内可见纤维化，这表明除了与人类CMV感染相关的更典型的内耳炎模式外，外淋巴腔内先前还存在迷路炎。球囊膜扩张明显。在耳蜗和前庭组织中，均有孤立的钙化区域，其表现与CID患者其他器官系统中报道的特征相符。总体而言，该CID病例中的这些慢性病理发现表明，其损伤比先前报道的CID急性颞骨病理所见更为广泛。
