Fitzgeorge R B, Lever S, Baskerville A
Public Health Laboratory Service Centre for Applied Microbiology and Research, Salisbury, Wiltshire, UK.
J Antimicrob Chemother. 1993 Jun;31 Suppl E:171-6. doi: 10.1093/jac/31.suppl_e.171.
The activities of two new macrolides, azithromycin and clarithromycin, were compared in an aerosol-infected guinea-pig model of legionnaires' disease. The results of this study indicate that a low oral dose of azithromycin (3.6 mg/kg) administered once daily gives 100% survival in Legionella pneumophila-infected animals. An eight-fold higher dose of clarithromycin (28.8 mg/kg) given twice-daily was required to achieve the same effect. Similarly, azithromycin was more effective than clarithromycin in preventing pyrexia and in reducing numbers of bacteria and lesions in the lung.
在军团病的气溶胶感染豚鼠模型中比较了两种新型大环内酯类药物阿奇霉素和克拉霉素的活性。本研究结果表明，每日口服一次低剂量阿奇霉素（3.6毫克/千克）可使感染嗜肺军团菌的动物存活率达到100%。而每日两次给予高八倍剂量的克拉霉素（28.8毫克/千克）才能达到相同效果。同样，在预防发热以及减少肺部细菌数量和损伤方面，阿奇霉素比克拉霉素更有效。
