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A comparative study on the efficacy of the new quinolone alatrofloxacin in the treatment of experimental legionellosis in guinea pigs.

作者信息

García-de-Lomas J, Millás E, Lázaro M A, Bermejo M, Gimeno C, Navarro D, Sánchez S

机构信息

Department of Microbiology, Faculty of Medicine, Hospital Clinic, Valencia, Spain.

出版信息

Eur J Clin Microbiol Infect Dis. 1998 Jun;17(6):420-3. doi: 10.1007/BF01691575.

DOI:10.1007/BF01691575
PMID:9758285
Abstract

The in vivo efficacy of trovafloxacin, intraperitoneally administered as alatrofloxacin (CP-116,517), was assessed and compared with that of erythromycin, alone or in combination with rifampicin, in a model of Legionella pneumophila pneumonia in guinea pigs. Trovafloxacin (5 mg/kg administered as alatrofloxacin once daily for 7 days) gave a survival rate of 100% in infected animals. Clearance of bacteria and of bacteria-induced lesions from lungs was achieved by day 6 post-inoculation. The lungs of trovafloxacin-treated animals remained free of bacteria at day 28 post-challenge. Trovafloxacin proved as effective as erythromycin administered intraperitoneally, but was superior to erythromycin alone. or in combination with rifampicin, when given orally.

摘要

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本文引用的文献

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Concentrations of trovafloxacin in bronchial mucosa, epithelial lining fluid, alveolar macrophages and serum after administration of single or multiple oral doses to patients undergoing fibre-optic bronchoscopy.
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Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral doses to healthy male volunteers.新型喹诺酮类抗生素曲伐沙星（CP-99,219）在健康男性志愿者单次口服给药后的药代动力学及安全性研究。
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