人血清中替代补体途径调控中β1H球蛋白和C3b灭活剂的要求。
Requirements for beta1H globulin and C3b inactivator in the control of the alternative complement pathway in human serum.
作者信息
Whaley K, Thompson R A
出版信息
Immunology. 1978 Dec;35(6):1045-9.
Abstract
Using beta1H-depleted and C3b inactivator (C3b1NA)-deficient sera we have investigated the regulatory roles of beta1H and C3bINA in the turnover of the alternative pathway. Spontaneous turnover of C3 and factor B occurred in both beta1H-depleted and C3bINA-deficient sera. In neither case was C3d generated. Prevention of activation could be achieved by the addition of the missing protein, but not by increasing the concentration of the remaining protein. Thus both beta1H and C3bINA must be present simultaneously to prevent spontaneous activation of the alternative pathway.
摘要
利用缺乏β1H和C3b灭活剂（C3bINA）的血清，我们研究了β1H和C3bINA在替代途径转换中的调节作用。在缺乏β1H和C3bINA的血清中均发生了C3和B因子的自发转换。两种情况下均未产生C3d。添加缺失的蛋白可实现激活的预防，但增加剩余蛋白的浓度则无法实现。因此，β1H和C3bINA必须同时存在才能防止替代途径的自发激活。
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