慢性肝病中的补体激活
Complement activation in chronic liver disease.
作者信息
Munoz L E, De Villiers D, Markham D, Whaley K, Thomas H C
出版信息
Clin Exp Immunol. 1982 Mar;47(3):548-54.
Abstract
Patients with HBsAg positive chronic active liver disease (CALD) and primary biliary cirrhosis (PBC) exhibit increased C3d concentrations and changes in the serum concentrations of the complement components consistent with activation of the classical and alternative pathways. In these patients the concentrations of the regulatory proteins, C3b inactivator (C3bINA) and beta IH globulin, are normal. Patients with HBsAg negative CALD and alcohol induced liver disease (ALD) exhibit no evidence of an increased level of complement system activation. In these patients diminished serum concentrations of complement components appear to be related to diminished hepatic synthetic function. C4 synthesis may be specifically reduced in autoimmune chronic active liver disease.
摘要
乙肝表面抗原（HBsAg）阳性的慢性活动性肝病（CALD）和原发性胆汁性肝硬化（PBC）患者表现出C3d浓度升高以及补体成分血清浓度变化，这与经典途径和替代途径的激活一致。在这些患者中，调节蛋白C3b灭活剂（C3bINA）和βIH球蛋白的浓度正常。乙肝表面抗原阴性的慢性活动性肝病患者和酒精性肝病（ALD）患者没有补体系统激活水平升高的迹象。在这些患者中，补体成分血清浓度降低似乎与肝脏合成功能降低有关。在自身免疫性慢性活动性肝病中，C4合成可能会特异性降低。
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