Landwehr D M, Carvalho J S, Oken D E
Kidney Int. 1977 Jan;11(1):9-17. doi: 10.1038/ki.1977.2.
The proximal tubular fluid albumin concentration of rats with immunologically induced nephrotic syndrome rose from 0.60 +/- 0.11 (SEM) mg/100 ml to 7.42 to 0.87 mg/100 ml. The glomerular filtration rate (GFR) was slightly depressed (P less than 0.001) and fractional water absorption unchanged (P greater than 0.45). Urinary albumin excretion rose from 0.18 +/- 0.03 (SEM) mg/100 g of body wt/24 hr to 78.5 +/- 39.5 mg/100 g/100 g of body wt/24 hr (P less than 0.001). The concentration of albumin in glomerular filtrate, calculated as the product of proximal tubular albumin concentration and fractional water absorption (4.53 +/- 0.60 mg [SEM]/100 ml), equalled that calculated from urine albumin concentration and whole kidney water absorption (4.14 +/- 0.84 mg/100 ml, P greater than 0.30). The data are interpreted to reflect a significant increase in filtered albumin and only a modest (if any) tubular albumin absorption in this study. Thus, the concept that tubular absorption plays a major role in the catabolism of albumin and the genesis of hypoalbuminemia in the nephrotic syndrome could not be confirmed.
免疫诱导性肾病综合征大鼠的近端肾小管液白蛋白浓度从0.60±0.11（标准误）mg/100 ml升至7.42至0.87 mg/100 ml。肾小球滤过率（GFR）略有下降（P<0.001），水重吸收率未变（P>0.45）。尿白蛋白排泄量从0.18±0.03（标准误）mg/100 g体重/24小时升至78.5±39.5 mg/100 g/100 g体重/24小时（P<0.001）。肾小球滤液中白蛋白浓度，计算方法为近端肾小管白蛋白浓度与水重吸收率的乘积（4.53±0.60 mg[标准误]/100 ml），与根据尿白蛋白浓度和全肾水重吸收率计算的值（4.14±0.84 mg/100 ml，P>0.30）相等。这些数据被解释为反映了本研究中滤过白蛋白的显著增加以及肾小管白蛋白重吸收仅适度增加（如果有增加的话）。因此，肾小管重吸收在肾病综合征白蛋白分解代谢和低白蛋白血症发生中起主要作用这一概念未得到证实。
