Taylor M F, Heckel D G, Brown T M, Kreitman M E, Black B
Department of Ecology and Evolutionary Biology, Princeton University, NJ 08544.
Insect Biochem Mol Biol. 1993 Oct;23(7):763-75. doi: 10.1016/0965-1748(93)90064-y.
Pyrethroids, with their lack of persistence and low mammalian toxicity, have been important insecticides since the early 1970s. However, heavy use has selected for resistance to pyrethroids in populations of many insects, in particular the tobacco budworm Heliothis virescens, a major cotton pest in the Americas. Several studies have identified the voltage-gated sodium channel as the principal target of pyrethroid action, and the sodium channel has been implicated in pyrethroid resistance in Musca domestica and Drosophila melanogaster. We present molecular genetic evidence that pyrethroid resistance is linked to a sodium channel locus in a strain of H. virescens. This is the first such evidence for any major agricultural pest, and is an important step towards understanding the molecular basis of resistance. This in turn will facilitate assessment, modeling, and control of resistance in pest populations, and increase our understanding of sodium channel function.
拟除虫菊酯由于其持效性差和对哺乳动物毒性低，自20世纪70年代初以来一直是重要的杀虫剂。然而，大量使用已导致许多昆虫种群对拟除虫菊酯产生抗性，尤其是烟草夜蛾，它是美洲主要的棉花害虫。多项研究已确定电压门控钠通道是拟除虫菊酯作用的主要靶点，并且钠通道与家蝇和黑腹果蝇的拟除虫菊酯抗性有关。我们提供了分子遗传学证据，表明拟除虫菊酯抗性与烟草夜蛾一个品系中的钠通道基因座有关。这是任何主要农业害虫的首个此类证据，是朝着理解抗性分子基础迈出的重要一步。这反过来将有助于评估、建模和控制害虫种群中的抗性，并增进我们对钠通道功能的理解。
