Hervet Caroline, Boullier Justine, Guiadeur Marlène, Michel Léa, Brun-Lafleur Laure, Aupiais Anne, Zhu Jianzhong, Mounaix Béatrice, Meurens François, Renois Fanny, Assié Sébastien
BIOEPAR, INRAE, Oniris, 44307 Nantes, France.
Institut de l'Élevage, 14310 Villers-Bocage, France.
Animals (Basel). 2021 May 25;11(6):1545. doi: 10.3390/ani11061545.
Bovine respiratory disease is still a major concern and has major economic impact. Another consequence of respiratory infections is the use of antimicrobial molecules to control bacterial pathogens. This can participate in the emergence and shedding of antimicrobial resistance that can threaten animal as well as human health. Appeasing pheromones with their capacity to reduce stress and thus their ability to preserve the functions of the immune system have been proposed to reduce the use of antimicrobial substances. In this study, we assessed the effect of appeasing pheromone administration on bovine health and performance during the fattening period. Zootechnical and health parameters and whole blood immune transcript expressions were measured over four weeks in bulls to determine the effect of the pheromone. We observed increased clinical signs on Day 8 (D8) and decreased clinical signs on D30 in bulls who received the pheromone and a higher expression of interleukin 8 transcripts in this group than in the control group on D8. Our results are overall in line with previous reports in livestock species. Further studies are needed to shed more light on the effect of appeasing pheromones and decipher their exact mechanisms of action.
牛呼吸道疾病仍然是一个主要问题，并具有重大的经济影响。呼吸道感染的另一个后果是使用抗菌分子来控制细菌病原体。这可能会促使抗菌药物耐药性的出现和传播，从而威胁动物和人类健康。有人提出，具有减轻压力能力从而能够维持免疫系统功能的安抚性信息素可以减少抗菌物质的使用。在本研究中，我们评估了在育肥期给予安抚性信息素对牛的健康和性能的影响。在公牛中，我们在四周内测量了畜牧技术和健康参数以及全血免疫转录本表达，以确定信息素的作用效果。我们观察到，接受信息素的公牛在第8天（D8）临床症状增加，而在第30天临床症状减少，并且该组中白细胞介素8转录本在D8时的表达高于对照组。我们的结果总体上与之前关于家畜物种的报告一致。需要进一步研究以更清楚地了解安抚性信息素的作用，并解读其确切作用机制。
