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人胸腺细胞上白细胞介素-7受体的连接对磷脂酰肌醇-3激酶的激活作用。

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.

作者信息

Dadi H K, Roifman C M

机构信息

Division of Immunology/Allergy, Hospital for Sick Children, Toronto, Ontario, Canada.

出版信息

J Clin Invest. 1993 Sep;92(3):1559-63. doi: 10.1172/JCI116736.

DOI:10.1172/JCI116736
PMID:8397227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC288304/
Abstract

Interleukin-7 (IL-7) is a glycoprotein that regulates lymphocyte precursor growth and differentiation. However, the exact mechanism whereby the IL-7 receptor (IL-7R) mediates these cell growth signals remains unknown. One of the earliest metabolic events linked to mitogenic responses in other growth factor receptor systems is the activation of phosphatidylinositol-3 kinase (PI-3 kinase). We demonstrate here that ligation of the IL-7R results in dose- and time-dependent increases in PI-3 kinase activity. These results suggest that PI-3 kinase is involved in signal transduction via the IL-7R in human thymocytes.

摘要

白细胞介素-7（IL-7）是一种调节淋巴细胞前体生长和分化的糖蛋白。然而，IL-7受体（IL-7R）介导这些细胞生长信号的确切机制仍不清楚。在其他生长因子受体系统中，与有丝分裂原反应相关的最早代谢事件之一是磷脂酰肌醇-3激酶（PI-3激酶）的激活。我们在此证明，IL-7R的连接导致PI-3激酶活性呈剂量和时间依赖性增加。这些结果表明，PI-3激酶参与了人胸腺细胞中通过IL-7R的信号转导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfde/288304/19c5bb149ff2/jcinvest00041-0457-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfde/288304/fa29d58ac462/jcinvest00041-0456-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfde/288304/19c5bb149ff2/jcinvest00041-0457-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfde/288304/fa29d58ac462/jcinvest00041-0456-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfde/288304/19c5bb149ff2/jcinvest00041-0457-a.jpg

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本文引用的文献

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