Whaley K J, Barratt R A, Zeitlin L, Hoen T E, Cone R A
Dept. of Biophysics, Johns Hopkins University, Baltimore MD 21218.
J Infect Dis. 1993 Oct;168(4):1009-11. doi: 10.1093/infdis/168.4.1009.
A vaginal application of a commercially available contraceptive jelly containing nonoxynol-9 (N9) prevented vaginal transmission of herpes simplex virus type 2 (HSV-2) infections in the mouse. When N9 jelly was delivered to the vagina with the virus inoculum, 20 s before inoculum, or 5 min before inoculum, mice were completely protected from visible infection (P < .001). Protection lasted for at least 30 min (P < .03), and significant protection occurred even when the N9 jelly was delivered 15 min after the HSV-2 inoculum (P < .05). These results are consistent with results of studies using N9 products in other animal models and suggest that N9-based contraceptive products can provide significant protection against vaginal transmission of enveloped virus infections in animals.
在小鼠中，阴道应用含有壬苯醇醚-9（N9）的市售避孕凝胶可预防单纯疱疹病毒2型（HSV-2）感染的阴道传播。当在接种病毒前20秒、接种前5分钟或接种前将N9凝胶递送至阴道时，小鼠完全免受可见感染（P <.001）。保护作用持续至少30分钟（P <.03），即使在HSV-2接种后15分钟递送N9凝胶时也出现显著保护作用（P <.05）。这些结果与在其他动物模型中使用N9产品的研究结果一致，并表明基于N9的避孕产品可对动物包膜病毒感染的阴道传播提供显著保护。
