Zacharopoulos V R, Phillips D M
Population Council, New York, New York 10021, USA.
Clin Diagn Lab Immunol. 1997 Jul;4(4):465-8. doi: 10.1128/cdli.4.4.465-468.1997.
The observations from the present study indicate that vaginal formulations of the sulfated polysaccharide carrageenan are highly effective in protecting mice from herpes simplex virus type 2 (HSV-2) infection. Test formulations were placed in the vaginas of progestin-treated mice prior to inoculation with HSV-2. Infection was determined by the presence of inflammation in the genital region and death. At a dose of virus that infected half of the control animals, 1% solutions of either lambda, kappa, or iota carrageenan prevented infection of almost all of the animals. Concentrations as low as 0.05% protected a large majority of the mice. At a dose of virus that infected all of the control mice, 1% solutions of carrageenans protected 85% of the inoculated mice. Other sulfated polysaccharides were less effective or showed no efficacy in preventing HSV-2 infection. These findings suggest that a vaginal formulation of carrageenan may be effective in blocking sexual transmission of HSV-2 in women.
本研究的观察结果表明，硫酸化多糖角叉菜胶的阴道制剂在保护小鼠免受2型单纯疱疹病毒（HSV-2）感染方面非常有效。在给用孕激素处理的小鼠接种HSV-2之前，将测试制剂置于其阴道内。通过生殖器区域的炎症和死亡情况来确定感染。在感染一半对照动物的病毒剂量下，1%的λ-、κ-或ι-角叉菜胶溶液可防止几乎所有动物感染。低至0.05%的浓度可保护绝大多数小鼠。在感染所有对照小鼠的病毒剂量下，1%的角叉菜胶溶液可保护85%的接种小鼠。其他硫酸化多糖在预防HSV-2感染方面效果较差或无效果。这些发现表明，角叉菜胶的阴道制剂可能有效地阻断女性中HSV-2的性传播。
