Chronic human schistosomiasis mansoni. Pathology of the Disse's space.

In chronic human schistosomiasis mansoni, the entire hepatic lobule is involved. The hepatovascular barrier is modified and shows hepatic sinusoids with hypertrophy and stratification of endothelium, basement membrane-like deposits, perisinusoidal fibrosis, diminution of hepatocellular microvilli and hepatocellular clasmatosis into the sinusoidal circulation. This transformation of an open circulation to a partly closed one may decrease the blood hepatocyte exchanges in schistosomiasis mansoni.