人源化抗体。
Humanized antibodies.
作者信息
Winter G, Harris W J
机构信息
MRC Laboratory of Molecular Biology, Cambridge, UK.
出版信息
Immunol Today. 1993 Jun;14(6):243-6. doi: 10.1016/0167-5699(93)90039-N.
PMID:8397764
Abstract
Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.
摘要
杂交瘤技术使针对人类病原体和细胞产生啮齿动物单克隆抗体成为可能，但这些抗体的临床应用有限。蛋白质工程目前正在通过对啮齿动物抗体进行“人源化”来生产用于治疗传染病、自身免疫性疾病和癌症的抗体。人源化抗体具有改善的药代动力学、降低的免疫原性，并已在临床上发挥了优势。
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