Hadden J W
Dept of Medicine, University of South Florida Medical College, Tampa 33612.
Immunol Today. 1993 Jun;14(6):275-80. doi: 10.1016/0167-5699(93)90045-M.
Nonspecific immunostimulation has progressed from crude microbially derived substances to chemically defined drugs with selective effects on different components of the immune system. John Hadden describes how immunopharmacological analyses of structure-activity relationships, pharmacokinetics and immunopharmacodynamics have directed the effective use of these agents in disease models and suggest that they may be of value in combination with other therapies in the treatment of immunodeficiencies, cancer, infections and even autoimmune disorders.
