Abramović B, Horváth K, Gaál F
Institute of Chemistry, Faculty of Sciences, University of Novi Sad, Yugoslavia.
J Pharm Biomed Anal. 1993 Jun;11(6):447-50. doi: 10.1016/0731-7085(93)80156-u.
Automatic titrimetric methods with catalytic, spectrophotometric and potentiometric monitoring of the course of titration were applied for determination of iodide content in iopanoic acid, 2-(3-amino-2,4,6-tri-iodobenzyl)butyric acid, as well as in the mixture of sodium amidotrizoate (sodium 3,5-diacetamido-2,4,6-tri-iodobenzoate), and meglumine amidotrizoate (N-methylglucamine salt of 3,5-diacetamido-2,4,6-tri-iodobenzoic acid), in some pharmaceutical contrasting preparations. After combustion of the sample in an oxygen atmosphere and absorption of products in hydrazine sulphate solution, the iodide present was titrated with a standard solution of silver nitrate. In catalytic titrations, the system persulphate-sulphanilic acid (acetate buffer pH 4.35) in the presence of 2,2'-bipyridine as an activator served as the indicator reaction. The results obtained were compared with those of the official methods. Amounts of iodide of about 1.2 mg per aliquot of analyte were determined with a standard deviation less than 1.9%.
采用具有催化、分光光度和电位滴定过程监测的自动滴定法，测定了碘番酸、2-(3-氨基-2,4,6-三碘苄基)丁酸以及一些药物造影剂制剂中泛影酸钠（3,5-二乙酰氨基-2,4,6-三碘苯甲酸酯钠）和葡甲胺泛影酸盐（3,5-二乙酰氨基-2,4,6-三碘苯甲酸的N-甲基葡糖胺盐）混合物中的碘化物含量。在氧气氛围中燃烧样品并将产物吸收于硫酸肼溶液后，用硝酸银标准溶液滴定其中存在的碘化物。在催化滴定中，以2,2'-联吡啶作为活化剂时，过硫酸盐-磺胺酸体系（pH 4.35的乙酸盐缓冲液）用作指示反应。将所得结果与官方方法的结果进行比较。每等分试样中碘化物含量约为1.2 mg，测定的标准偏差小于1.9%。
