Wiedemann G, Jonetz-Mentzel L
Klinisch-Chemisches Labor der Klinik und Poliklinik für Kindermedizin, Medizinischen Hochschule, Erfurt, Germany.
Eur J Clin Chem Clin Biochem. 1993 Jul;31(7):447-51.
Prolactin was determined in the sera of 686 healthy neonates, infants, children and adolescents (age range 5 days to 18 years), using the IMx from Abbott Laboratories. The applied test was a microparticle enzyme immunoassay (MEIA). The proband collective was divided into 9 age groups, and each age group into males and females. In accordance with the recommendations of the International Federation of Clinical Chemistry, the 95% scatter range was taken as the reference range. Only a few reference groups showed a normal Gaussian distribution. In addition to the 50th percentile, the 2.5th and 97.5th percentile were calculated for all reference groups, and the minimal and maximal values were also reported. From the age of 12 years onwards, significant differences were found between males and females. The U-test of Mann & Whitney was used to test for significant differences between individual reference groups. Groups showing no significant differences were combined, and the corresponding reference ranges for serum prolactin were then calculated.
采用雅培实验室的IMx测定了686名健康新生儿、婴儿、儿童及青少年（年龄范围为5天至18岁）血清中的催乳素。所应用的检测方法为微粒体酶免疫测定法（MEIA）。将受检人群分为9个年龄组，每个年龄组再分为男性和女性。根据国际临床化学联合会的建议，将95%散布范围作为参考范围。只有少数参考组呈现正态高斯分布。除了计算第50百分位数外，还为所有参考组计算了第2.5和第97.5百分位数，并报告了最小值和最大值。从12岁起，男性和女性之间发现了显著差异。采用曼-惠特尼U检验来检测各个参考组之间的显著差异。将无显著差异的组合并，然后计算血清催乳素的相应参考范围。
