Wiedemann G, Jonetz-Mentzel L
Klinisch-Chemisches Labor der Klinik und Poliklinik für Kindermedizin, Medizinischen Hochschule, Erfurt, Germany.
Eur J Clin Chem Clin Biochem. 1993 Jul;31(7):453-7.
Ferritin was determined in the sera of 631 healthy neonates, infants, children and adolescents (age range 5 days to 18 years), using the IMx from Abbott Laboratories. The applied test was a microparticle enzyme immunoassay (MEIA). The proband collective was divided into 9 age groups, and each group into males and females. In accordance with the recommendations of the International Federation of Clinical Chemistry, the 95% scatter range was taken as the reference range. Only a few reference groups showed a normal Gaussian distribution. In addition to the 50th percentile, the 2.5th and 97.5th percentile were calculated for all reference groups, and the minimal and maximal values were also reported. Significantly different reference ranges were found for males and females in the age group 16-18 years. The U-test of Mann & Whitney was used to test for significant differences between individual reference groups. Groups showing no significant differences were combined, and the corresponding reference ranges for serum ferritin were then calculated.
采用雅培公司的IMx测定了631名健康新生儿、婴儿、儿童及青少年（年龄范围为5天至18岁）血清中的铁蛋白。所应用的检测方法为微粒体酶免疫测定法（MEIA）。将研究对象群体分为9个年龄组，每组再分为男性和女性。根据国际临床化学联合会的建议，将95%的散布范围作为参考范围。只有少数参考组呈现出正常的高斯分布。除计算第50百分位数外，还为所有参考组计算了第2.5和第97.5百分位数，并报告了最小值和最大值。在16 - 18岁年龄组中，发现男性和女性的参考范围存在显著差异。采用曼 - 惠特尼U检验来检验各个参考组之间的显著差异。将无显著差异的组合并，然后计算血清铁蛋白的相应参考范围。
