Sweeney J A, Clementz B A, Escobar M D, Li S, Pauler D K, Haas G L
Department of Psychiatry, University of Pittsburgh, PA.
Biol Psychiatry. 1993 Sep 1;34(5):331-40. doi: 10.1016/0006-3223(93)90090-z.
Results of two recent studies suggest that a distinct subgroup of schizophrenic patients and their relatives have particularly deviant eye tracking. Such heterogeneity could be of considerable importance, as it may indicate significant pathophysiologic or etiologic heterogeneity in schizophrenia. An analysis of 101 consecutive-admission schizophrenic patients confirmed the existence of two distinct subgroups of patients with higher and lower levels of spatial [root mean square (RMS)] eye-tracking error. However, there was no heterogeneity in the disturbance of pursuit eye movements. Anticipatory saccades, which by definition add very large amounts of spatial tracking error, were more frequent in the "high" RMS error group. Rates of anticipatory saccades were similar in the "low" RMS error patient group and normal controls, and there was no heterogeneity in the expression of anticipatory saccades. Apparent heterogeneity in global indices of eye-tracking impairment in schizophrenia appears to be a measurement artifact reflecting the powerful influence of anticipatory saccades on global performance indices, rather than true heterogeneity in the expression of any specific eye movement abnormality.
最近两项研究的结果表明，一个独特的精神分裂症患者亚组及其亲属具有特别异常的眼球跟踪。这种异质性可能相当重要，因为它可能表明精神分裂症存在显著的病理生理或病因异质性。对101例连续入院的精神分裂症患者进行的分析证实，存在两个不同的亚组，即空间[均方根（RMS）]眼球跟踪误差水平较高和较低的患者。然而，追踪眼球运动的障碍并无异质性。根据定义，预期性扫视会增加大量的空间跟踪误差，在“高”RMS误差组中更为频繁。“低”RMS误差患者组和正常对照组的预期性扫视发生率相似，预期性扫视的表现也没有异质性。精神分裂症患者眼球跟踪损伤整体指标中明显的异质性似乎是一种测量假象，反映了预期性扫视对整体表现指标的强大影响，而非任何特定眼球运动异常表现的真正异质性。
