Mastrangelo G, Serena R, Marzia V
Istituto di Medicina del Lavoro, Università di Padova, Italy.
Occup Med (Lond). 1993 Aug;43(3):155-8. doi: 10.1093/occmed/43.3.155.
A retrospective epidemiological cohort study of mortality was undertaken in 671 workers with at least 12 months' exposure to acrylonitrile (AN) in an acrylic fibre factory at Porto Marghera, Venezia; 571 subjects had simultaneous exposure to dimethylacetamide (DMA). Observed mortality in the cohort was compared with expected mortality, calculated on the basis of the mortality rates of the general population in the Veneto region. A statistically significant excess was found in the mortality rate from intestinal and colon tumours (SMR = 10.5, 4 observed). However, this finding was significant only in subgroups with 1 to 4 years exposure or 1 to 9 years latency. It is therefore concluded that there is no relationship between AN and/or DMA exposure and mortality from tumours of the colon and intestine.
在威尼斯马尔盖拉港的一家腈纶纤维厂，对671名至少接触丙烯腈（AN）12个月的工人进行了一项关于死亡率的回顾性流行病学队列研究；571名受试者同时接触二甲基乙酰胺（DMA）。将该队列中的观察到的死亡率与根据威尼托地区普通人群死亡率计算出的预期死亡率进行比较。发现肠道和结肠肿瘤的死亡率存在统计学上的显著超额（标准化死亡比=10.5，观察到4例）。然而，这一发现仅在接触1至4年或潜伏期1至9年的亚组中具有显著性。因此得出结论，接触AN和/或DMA与结肠和肠道肿瘤的死亡率之间没有关系。
