Sala-Serra M, Sunyer J, Kogevinas M, McFarlane D, Antó J M
Department of Epidemiology and Public Health, Universitat Autònoma de Barcelona, Spain.
Am J Ind Med. 1996 Jul;30(1):87-92. doi: 10.1002/(SICI)1097-0274(199607)30:1<87::AID-AJIM15>3.0.CO;2-4.
We examined mortality in a retrospective follow-up study of 3,241 workers employed between 1970-1992, in four pulp and paper mills in Catalonia, Spain. Vital status was determined for 95% of the cohort. Exposure was reconstructed using job histories and a company exposure questionnaire. Standardized mortality ratios (SMR) were derived using mortality rates of Spain as the reference. For all workers, mortality from all causes (SMR = 76; 95%; confidence intervals [CI] = 65-88; 189 deaths) and all malignant neoplasms (SMR = 93; CI = 72-119; 65 deaths) were less than the expected. Excess risk was observed for mortality from all neoplasms in females (SMR = 168; CI = 84-303; 11 deaths), for large intestine cancer in both sexes (SMR = 250; CI = 115-525; 8 deaths), particularly after 10 years of employment and latency (SMR = 355; CI = 154-701; 8 deaths), and for breast cancer in females (SMR = 286; CI = 77-732; 4 deaths). These findings suggest that workers employed in the pulp and paper industry may have an excess risk of specific cancers.
我们对1970年至1992年间在西班牙加泰罗尼亚的四家纸浆和造纸厂工作的3241名工人进行了一项回顾性随访研究，以调查死亡率。确定了该队列中95%人员的生命状况。利用工作经历和公司暴露情况调查问卷对暴露情况进行了重建。以西班牙的死亡率作为参考得出标准化死亡比（SMR）。对于所有工人，全因死亡率（SMR = 76；95%置信区间[CI] = 65 - 88；189例死亡）和所有恶性肿瘤死亡率（SMR = 93；CI = 72 - 119；65例死亡）均低于预期。在女性中观察到所有肿瘤的死亡存在超额风险（SMR = 168；CI = 84 - 303；11例死亡），在男性和女性中结肠癌均存在超额风险（SMR = 250；CI = 115 - 525；8例死亡），尤其是在工作10年及更长潜伏期后（SMR = 355；CI = 154 - 701；8例死亡），以及女性乳腺癌存在超额风险（SMR = 286；CI = 77 - 732；4例死亡）。这些发现表明，纸浆和造纸行业的工人可能存在特定癌症的超额风险。
