几种光敏剂对兔红细胞的诱导光解作用。
Induced photolysis of rabbit red blood cells by several photosensitizers.
作者信息
Juarranz A, Villanueva A, Díaz V, Rodríguez-Borlado L, Trigueros C, Cañete M
机构信息
Deparmento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
出版信息
Anticancer Drugs. 1993 Aug;4(4):501-4. doi: 10.1097/00001813-199308000-00012.
The photolysis of rabbit red blood cells induced by several photosensitizers has been studied. Membrane photohemolysis was found to be dependent on light dose (J/cm2) for hematoporphyrin (HP), methylene blue (MB) and toluidine blue (TB). No significant hemolysis was detected when mesotetra (4N-methylpyridyl) porphine (T4MPyP) plus light was used. Sodium azide inhibited, whereas deuterium oxide potentiated membrane lysis with HP, MB and TB. In the case of T4MPyP no differences were observed when using sodium azide or deuterium oxide.
已经研究了几种光敏剂诱导的兔红细胞光解。发现膜光溶血取决于血卟啉（HP）、亚甲蓝（MB）和甲苯胺蓝（TB）的光剂量（J/cm²）。当使用中-四（4-N-甲基吡啶基）卟啉（T4MPyP）加光时，未检测到明显的溶血。叠氮化钠抑制了HP、MB和TB诱导的膜裂解，而重水则增强了这种作用。对于T4MPyP，使用叠氮化钠或重水时未观察到差异。
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