de Crespigny A J, Tsuura M, Moseley M E, Kucharczyk J
Department of Radiology, University of California, San Francisco 94143.
J Magn Reson Imaging. 1993 Sep-Oct;3(5):746-54. doi: 10.1002/jmri.1880030510.
A carotid embolic stroke model in rats was studied with a combination of diffusion- and perfusion-sensitive magnetic resonance (MR) imaging at 4.7 T. Capillary blood deoxygenation changes were monitored during formation of focal ischemia by acquiring multisection magnetic susceptibility-weighted echo-planar images. A signal intensity decrease of 7% +/- 3 in ischemic brain (1% +/- 2 in normal brain) was attributable to a T2* decrease due to increased blood deoxygenation, which correlated well with subsequently measured decreases in the apparent diffusion coefficient. The same multisection methods were used to track the first-pass transit of a bolus of dysprosium-DTPA-BMA [diethylenetriaminepentaacetic acid-bis(methylamide)] to assess relative tissue perfusion before and after stroke and after treatment with a thrombolytic agent. Analysis of contrast agent transit profiles suggested a total perfusion deficit in ischemic tissue and essentially unchanged perfusion in normal brain tissue after stroke.
采用4.7T的扩散和灌注敏感磁共振成像相结合的方法，对大鼠颈动脉栓塞性中风模型进行了研究。通过采集多层面磁敏感加权回波平面图像，在局灶性缺血形成过程中监测毛细血管血液脱氧变化。缺血脑组织信号强度下降7%±3（正常脑组织为1%±2），这归因于血液脱氧增加导致的T2*下降，这与随后测量的表观扩散系数下降密切相关。采用相同的多层面方法追踪镝-二乙三胺五乙酸双甲酰胺（diethylenetriaminepentaacetic acid-bis(methylamide)）团注的首次通过情况，以评估中风前后及溶栓治疗后的相对组织灌注。造影剂通过曲线分析表明，缺血组织存在完全灌注不足，中风后正常脑组织灌注基本不变。
