de Crespigny A J, Wendland M F, Derugin N, Vexler Z S, Moseley M E
Department of Radiology, University of California, San Francisco 94143.
J Magn Reson Imaging. 1993 May-Jun;3(3):475-81. doi: 10.1002/jmri.1880030308.
Deoxygenated blood was effectively used as a magnetic resonance (MR) susceptibility contrast agent to distinguish perfused and nonperfused (ischemic) regions in a focal ischemia model in cat brain at 2T. Modulation of cerebral blood oxygenation levels in response to apnea was followed in real time with T2*-weighted (gradient-recalled) echo-planar MR imaging. Signal loss in the T2*-weighted images occurred only in perfused tissues as blood became globally deoxygenated. These data complemented information from diffusion-weighted and contrast agent bolus-tracking images. In addition, observation of the signal recovery behavior on reventilation in both normal and ischemic brain offered potentially useful information about the state of the cerebral autoregulatory mechanism.
在2T场强下，在猫脑局灶性缺血模型中，脱氧血液被有效地用作磁共振（MR）敏感性对比剂，以区分灌注区和非灌注（缺血）区。通过T2加权（梯度回波）回波平面MR成像实时跟踪呼吸暂停时脑血氧水平的变化。随着血液整体脱氧，T2加权图像中的信号丢失仅发生在灌注组织中。这些数据补充了来自扩散加权和对比剂团注追踪图像的信息。此外，观察正常和缺血性脑再通气时的信号恢复行为，可为脑自动调节机制的状态提供潜在有用信息。
