Narita T, Funahashi H, Satoh Y, Takagi H
Second Department of Surgery, Nagoya University School of Medicine, Japan.
Surg Today. 1993;23(8):682-6. doi: 10.1007/BF00311705.
We investigated the usefulness of serum levels of procollagen type III N-peptide (P III P) and the type IV collagen, 7S-domain, (IV-C) as markers of recurrent and metastatic breast cancer. Serum P III P and IV-C levels were found to be significantly higher in patients who showed postoperative recurrence, with 76.9% of P III P-positive cancer bearing patients and 68.0% of IV-C-positive cancer bearing patients having metastases in the bone and/or liver. Furthermore, 66.7% of all patients with metastases in the bone and/or liver were P III P-positive and 75.6% were IV-C-positive. Patients with liver metastases were either P III P- or IV-C-positive, and the levels were higher than those in patients with bone metastases. Thus, a positive correlation of serum P III P and IV-C levels was observed. These findings suggest that both serum P III P and IV-C levels are useful markers of recurrent and metastatic breast cancer, especially of disease in the bone and/or liver.
我们研究了血清III型前胶原N端肽（P III P）和IV型胶原7S结构域（IV-C）水平作为复发性和转移性乳腺癌标志物的实用性。结果发现，术后复发患者的血清P III P和IV-C水平显著更高，76.9%的P III P阳性癌症患者和68.0%的IV-C阳性癌症患者出现骨和/或肝转移。此外，所有骨和/或肝转移患者中，66.7%为P III P阳性，75.6%为IV-C阳性。肝转移患者要么P III P阳性，要么IV-C阳性，且其水平高于骨转移患者。因此，观察到血清P III P和IV-C水平呈正相关。这些发现表明，血清P III P和IV-C水平都是复发性和转移性乳腺癌，尤其是骨和/或肝疾病的有用标志物。
