Chen C Y, Chen W X, Sun X
Nanjing Institute of Biochemical Pharmacy.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Apr;13(4):226-7, 198.
Bee venom 1.0-2.0 mg/kg and bee venom peptides 1.0-2.0 mg/kg inhibited several inflammatory processes, such as ear swelling induced by xylene in mice, edema produced by injecting 1% carrageenin 0.1 ml beneath the plantar surface of hind paw in rats and showed a marked analgesic action induced by the hot plate and potassium antimony tartrate. Bee venom peptides had a markedly more effective action as compared with bee venom itself. The anaphylactogenicity of bee venom peptides was apparently milder than that of bee venom. The LD50 of bee venom ip in mice and bee venom peptides was 7.4 mg/kg and 7.9 mg/kg respectively.
蜂毒1.0 - 2.0毫克/千克和蜂毒肽1.0 - 2.0毫克/千克可抑制多种炎症过程，如二甲苯诱导的小鼠耳部肿胀、在大鼠后爪足底皮下注射0.1毫升1%角叉菜胶所产生的水肿，并且对热板法和酒石酸锑钾诱导的疼痛显示出显著的镇痛作用。与蜂毒本身相比，蜂毒肽的作用明显更有效。蜂毒肽的致敏性明显比蜂毒轻。小鼠腹腔注射蜂毒和蜂毒肽的半数致死量分别为7.4毫克/千克和7.9毫克/千克。
